Two sample MR report
SPATA20_Dendritic Cell (DC) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0013673 | 0.0918885 | 0.9888405 |
| Weighted median | 6 | 0.0170417 | 0.0076151 | 0.0252291 |
| Inverse variance weighted | 6 | 0.0155534 | 0.0062576 | 0.0129366 |
| Simple mode | 6 | 0.0171863 | 0.0105887 | 0.1654998 |
| Weighted mode | 6 | 0.0170975 | 0.0097709 | 0.1405498 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.573172 | 4 | 0.8136056 |
| Inverse variance weighted | 1.607239 | 5 | 0.9003726 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0137729 | 0.0746208 | 0.8625448 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 9.59e-05 | 0 | TRUE | 0.3523081 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
